AOC Research & Innovation
Our doctors are shaping the future of orthopedics through research and publications that guide the advanced care we provide every day .
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Angiotensin II Stimulates Calcineurin Activity in Proximal Tubule Epithelia through AT-1 Receptor-Mediated Tyrosine Phosphorylation of the PLC-γ1 Isoform
Author Dr. Michael S Shuler, et al. Journal Journal of the American Society of Nephrology, Volume 13 – Issue 7 Summary This study explores how angiotensin II (AngII) regulates sodium transport in proximal tubule epithelial cells. Researchers found that AngII rapidly activates calcineurin through AT-1 receptor–mediated tyrosine phosphorylation of phospholipase C (PLC), linking AngII signaling…
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